IndraLab

Statements

USP10 binds MAPT. 8 / 8
| 3 5
sparser
"Inhibition of USP10-Tau interaction might be therapeutically useful in the management of AD and related tauopathies."
35987808
reach
"Results from mass spectrometry, reciprocal immunoprecipitation, and immunofluorescence assays strongly prove Tau's interaction with USP10."
35987808
reach
"Moreover, in primary neuronal cultures, Aβ 42 induces a dose-dependent USP10 upregulation, an increase in the levels of both total and phosphorylated Tau, as well as a markedly elevated Tau binding with USP10, that is accompanied by a significantly decreased Tau ubiquitination."
35987808
sparser
"Results from mass spectrometry, reciprocal immunoprecipitation, and immunofluorescence assays strongly prove Tau's interaction with USP10."
35987808
sparser
"This is further supported by the Tau307-326K and Tau341-378K peptides' competitive inhibition of Tau binding with USP10, attenuating Tau hyperphosphorylation and Tau deubiquitination."
35987808
reach
"This is further supported by the Tau307-326K and Tau341-378K peptides' competitive inhibition of Tau binding with USP10, attenuating Tau hyperphosphorylation and Tau deubiquitination."
35987808
sparser
"Moreover, in primary neuronal cultures, Aβ 42 induces a dose-dependent USP10 upregulation, an increase in the levels of both total and phosphorylated Tau, as well as a markedly elevated Tau binding with USP10, that is accompanied by a significantly decreased Tau ubiquitination."
35987808
sparser
"The association of ubiquitin with neurofibrillary tangles is also well documented, xref in line with shreds of evidence related to Ubiquitin‐specific protease 10 (USP10) as a crucial factor for the formation of SGs comprising tau, TIA‐1, and USP10. xref USP10 also colocalizes with aggregated tau in AD patients' brain lesions, xref suggesting its role in SG mediated tau aggregation."
33930220