IndraLab

Statements

ACVR2A activates SMAD2. 5 / 6
| 4 1
reach
"Activin performs its function through Acvr2a, which is required for binding Activin to cause downstream p-SMAD2 activation, thus initiating Activin signaling."
25458897
sparser
"Two subunits of Inhba form the homodimer Activin A, which signals through canonical ALK4-ACVR2 receptor complexes activating the transcription factors SMAD2 and SMAD3."
| PMC
reach
"(A) Endogenous ActRII signaling via phosphorylation (P) of Smad2 and Smad3."
34520530
reach
"In ACVR2A/B dKO parental cells, only ACVR2A , but not ACVR2A , could rescue both pSMAD2 and pSMAD1/5 (Fig 4B)."
34003511
reach
"Similarly, in ACVR2A/B dKO HOM1 cells, ACVR2A could restore both pSMAD2 and pSMAD1/5."
34003511