IndraLab

Statements

TP53-R273H increases the amount of TP53. 2 / 2
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"Although there was no significant difference in expression of CDKN1A, VDR, and TP53INP1 between CD24 + PC3 cells and CD24 - PC3 cells, the transfections of WT TP53, mutants TP53 R273H, TP53 V143A, and TP53 R280T, but not mutant TP53 R175H, induced the expression of these p53 target genes in CD24 - PC3 cells but not in CD24 + PC3 cells (XREF_FIG)."
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"TP53 R273H mutation, which lies within the DNA-binding domain of the tumor-suppressor protein Tp53, is responsible for the loss of DNA binding and decreased activation of Tp53 target gene expression."
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