IndraLab

Statements

BAP1 activates DNA repair. 19 / 19
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"BAP1 is recruited to double strand breaks ( DSB ) and promotes DNA repair and survival after DNA damage induction [ 18,19,20 ] ."
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage , and promote DNA repair by regulating the accumulation of repair proteins ( BRCA1 , RAD51 , and RPA ) ( 7 ) ."
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"In the nucleus, BAP1 modulates the transcriptional regulation of several gene programs and promotes DNA repair by facilitating homologous recombination ."
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"Indeed, by using a green fluorescent protein (GFP)-based reporter assay employing a recognition site for the rare-cutting I-SceI endonuclease for induction of DSBs , we found that loss of BAP1 caused a substantial reduction of GFP-positive cells, indicating loss of proper DNA repair (Supplementary Fig. 5k)."
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"Interestingly, BRCA1 proteins were decreased in the MM cells with BAP1 deletion, and transduction of the mutants as well as WT BAP1 increased BRCA1 proteins, suggesting that BAP1 may promote DNA repair partly through stabilizing BRCA1."
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"Although LOH of additional genes within Chr 3p21.1 may contribute to tumor suppression, and loss of BAP1 in pancreatic cancer may be secondary—rather than the cause of genomic instability—our mouse model suggests Bap1 ablation suffices to cause defective DNA repair, pancreatitis, and cooperates with oncogenic Kras to promote pancreatic cancer."
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"BAP1 promotes DNA repair , regulates transcription , cell differentiation , and cell death 23 ."
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"Reduced BAP1 levels impair DNA repair as well as different forms of cell death and induce metabolic alterations that together favor cancer development and growth."
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"Additionally, BAP1 modulates transcription, DNA repair, and replication by regulating chromatin remodeling via histone H2AK119 deubiquitination (12)."
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"It is expected that BAP1 promotes tumorigenesis of CCA by modulating DNA repair, gene transcription, and post-translational modification, such as glycosylation."
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"Given the role of BAP1 in HR repair and RAD51 recruitment , BAP1 may also contribute to the restart of stalled forks by directly promoting DNA repair at collapsed forks."
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"BAP1 promotes double-strand DNA repair by homologous recombination (HR), a key process to reduce genetic damage and prevent cancer."
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"In heterozygous BAP1 +/- conditions, as in family members affected by the BAP1 cancer syndrome, the reduced BAP1 levels impair both DNA repair, making their cells accumulate more DNA damage, and the apoptotic response."
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"Though direct evidence that BAP1 mediates DNA repair is lacking, we can still imply from the other 3p gene SETD2 that also belongs to histone modifier."
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"Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy."
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"Reduced BAP1 levels impair DNA repair ( 11 ) as well as different forms of cell death ( 3 , 12 ) and induce metabolic alterations ( 13-15 ) that together favor cancer development and growth ."
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"Most of them are involved in DNA repair signaling, including MLH1, BRCA1/2, MUTYH, ATM, PMS2, MSH6, BAP1, and FANCA."
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"The study showed that BAP1 is recruited to sites of UV-induced DNA damage via H2A-K119-Ub and PARP1 to promote DNA repair and that both DUB activity and PARP1-mediated poly(ADP-ribosyl)ation are critical for this function of BAP1 ."
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