IndraLab

Statements

BAP1 activates DNA repair. 13 / 13
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"Most of them are involved in DNA repair signaling, including MLH1, BRCA1/2, MUTYH, ATM, PMS2, MSH6, BAP1, and FANCA."
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"Indeed, by using a green fluorescent protein (GFP)-based reporter assay employing a recognition site for the rare-cutting I-SceI endonuclease for induction of DSBs , we found that loss of BAP1 caused a substantial reduction of GFP-positive cells, indicating loss of proper DNA repair (Supplementary Fig. 5k)."
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
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"BAP1 promotes double-strand DNA repair by homologous recombination (HR), a key process to reduce genetic damage and prevent cancer."
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"Reduced BAP1 levels impair DNA repair as well as different forms of cell death and induce metabolic alterations that together favor cancer development and growth."
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage , and promote DNA repair by regulating the accumulation of repair proteins ( BRCA1 , RAD51 , and RPA ) ( 7 ) ."
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"Reduced BAP1 levels impair DNA repair ( 11 ) as well as different forms of cell death ( 3 , 12 ) and induce metabolic alterations ( 13-15 ) that together favor cancer development and growth ."
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"Although LOH of additional genes within Chr 3p21.1 may contribute to tumor suppression, and loss of BAP1 in pancreatic cancer may be secondary—rather than the cause of genomic instability—our mouse model suggests Bap1 ablation suffices to cause defective DNA repair, pancreatitis, and cooperates with oncogenic Kras to promote pancreatic cancer."
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"Interestingly, BRCA1 proteins were decreased in the MM cells with BAP1 deletion, and transduction of the mutants as well as WT BAP1 increased BRCA1 proteins, suggesting that BAP1 may promote DNA repair partly through stabilizing BRCA1."
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"In heterozygous BAP1 +/- conditions, as in family members affected by the BAP1 cancer syndrome, the reduced BAP1 levels impair both DNA repair, making their cells accumulate more DNA damage, and the apoptotic response."
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"BAP1 promotes DNA repair , regulates transcription , cell differentiation , and cell death 23 ."
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"In the nucleus, BAP1 modulates the transcriptional regulation of several gene programs and promotes DNA repair by facilitating homologous recombination ."
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"BAP1 is recruited to double strand breaks ( DSB ) and promotes DNA repair and survival after DNA damage induction [ 18,19,20 ] ."
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