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17beta-estradiol activates KCNMA1. 19 / 20
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"17beta-Estradiol (100 nM) caused a significant increase in the frequency of TBKCs (XREF_FIG), indicating that 17beta-estradiol positively modulates BK channel activity in UBSM cells."
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"Directly confirming the 17beta-estradiol-BK channel functional interactions, we found that 17beta-estradiol (100 nM) significantly increased the single BK channel NP o of inside-out excised membrane patches of UBSM cells (XREF_FIG)."
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"It will be interesting to see whether BK channel activity in neurons can be modulated by 17beta-estradiol application and how steroid hormone induced opening of neuronal BK channels may affect neurona[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10828459
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"2002), 17beta-estradiol increased BK channel activity through a direct interaction with the regulatory beta 1 -subunit of the BK channel."
28754781
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No evidence text available
18068743
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"Estradiol treatment increased KCNMA1 mRNA and protein expression in all groups; however, the highest levels were observed in the transgenic mice with carcinoma."
29725443
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"17beta-Estradiol can modulate BK channel activity by binding to the regulatory BK channel beta 1 -subunit (Valverde etal."
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"In addition, Valverde et al. (1999) have shown that 17beta-oestradiol activates Maxi-K + channels in Xenopus leavis oocytes by binding to the Maxi-K + channels at the regulatory beta subunit.The abili[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12969759
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"The xenoestrogen, tamoxifen, and the endogenous steroid hormone 17beta-estradiol were also found to activate the BK channel in a beta1- dependent manner."
27238261
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"In addition, Valverde et al. (1999) also demonstrated that Maxi-K + channels were activated by 17beta-oestradiol, which directly bound to the beta-subunit of Maxi-K + channels in Xenopus laevis oocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12969759
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"17beta-estradiol (E2) increases the BK channel open probability (P o) in SMCs, through a beta1 subunit dependent modulatory effect."
31292456
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"17beta-estradiol stimulates Maxi-K channel of the rabbit cavernous myocyte."
15154087
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"Therefore, 17beta-estradiol increased the number of small BK channel opening events reaching the TBKC threshold of 9pA, (see Materials and Methods) as a result of direct modulation of BK channel NPo, while having no potentiating effects on the average amplitude of TBKCs in DSM cells."
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"17beta-Estradiol (100nmol/L) significantly increased the single BK channel NPo from 0.086 +/-0.030 to 0.137 +/-0.030 (n = 9, N = 7, P < 0.05; Fig."
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"17beta-Estradiol increases single BK channel open probability in the excised membrane patches of human DSM cells."
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"The present investigation demonstrates that 17beta-oestradiol activates the BK channel complex by increasing the burst duration of channel openings."
17060159
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"KCNMA1-function in breast cancer cell lines was confirmed by whole-cell patch clamp recordings and proliferation assays, using siRNA-knockdown, BK channel activators such as 17beta-estradiol and the BK-channel blocker paxilline."
22899999
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"17beta-Estradiol (100 nM) increased the mean BK channel NP o from the control value of 0.05 +/-0.03 to 0.20 +/-0.07 (n = 13, N = 11; P < 0.05)."
26536038
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"The present investigation demonstrates that 17beta-oestradiol activates the BK channel complex by increasing the burst duration of channel openings."
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