IndraLab

Statements

TNFAIP3 inhibits autophagy. 8 / 8
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"Thus , A20 deficiency in mice triggers inflammation and autoimmune disorders and might eventually lead to death.13 , 14 , 15 , 16 Many studies have reported that A20 overexpression in human periodontal ligament cells ( hPDLCs ) decreases RANKL-induced osteoclastogenesis in mouse bone marrow-derived macrophages ( BMMs ) and that A20 can inhibit autophagy through limiting the K63-linkage ubiquitination of TRAF6 , or by directly deubiquitinating Beclin1.17 , 18 Numerous studies have shown that periodontal tissues are in a hypoxic microenvironment during periodontitis ."
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"TRAF6 K63-linked ubiquitination of Beclin 1 was shown to induce autophagy [ xref ]; suggesting a possible feedback loop, the authors also demonstrated that A20 inhibits autophagy by deubiquitinating Beclin 1, thereby inhibiting the autophagy-activating ubiquitination by TRAF6."
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"XREF_BIBR In contrast, the deubiquitinase TNFAIP3 and A20 reduces TLR4 triggered autophagy by decreasing K63 ubiquitination of BECN1."
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"The results of this study showed that TNFAIP3 significantly reduces inflammatory response and ameliorates the degradation of the extracellular matrix by promoting autophagy in LPS-induced-inflammatory human NPCs that mimics IVDD."
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"27 In other studies , A20 silencing has been found to promote basal LC3 conversion in HeLa cells as well as ATG16L1 expression in the intestinal epithelium.28 , 29 Therefore , we can conclude that A20 may inhibit autophagy ."
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"Simultaneously, TNFAIP3 also decreased the secretion of inflammatory corpuscles by promoting autophagy in Ankylosing spondylitis [XREF_BIBR]."
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"In our study , it was proved that A20 inhibited autophagy , reduced TRAF6 expression and decreased the number of TRAP-positive osteoclasts and the areas of hydroxyapatite resorption ."
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"It has been reported that K48-linked polyubiquitin chains promoted the degradation of proteasome , while K63-linked polyubiquitin chains mediate ubiquitination.22 Thus , these results showed that A20 may suppress autophagy through promoting the degradation of TRAF6 and inhibiting the ubiquitination of TRAF6 ."
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