IndraLab

Statements

TNFAIP3 inhibits autophagy. 10 / 10
| 4 5 1
reach
"The results of this study showed that TNFAIP3 significantly reduces inflammatory response and ameliorates the degradation of the extracellular matrix by promoting autophagy in LPS-induced-inflammatory human NPCs that mimics IVDD."
33226960
reach
"The reduced mitochondrial content could result from increased autophagy mediated by the upregulation of Tnfaip3, since Tnfaip3 deficiency has been shown to increase mitochondrial content in CD4 cells by promoting autophagy , or from reduced CD4 cell growth.Pathway analysis further supports a compromised effector function of CD4 cells from MMTV-Her2 mice."
38645169
reach
"Simultaneously, TNFAIP3 also decreased the secretion of inflammatory corpuscles by promoting autophagy in Ankylosing spondylitis [XREF_BIBR]."
33226960
reach
"XREF_BIBR In contrast, the deubiquitinase TNFAIP3 and A20 reduces TLR4 triggered autophagy by decreasing K63 ubiquitination of BECN1."
29251248
eidos
"27 In other studies , A20 silencing has been found to promote basal LC3 conversion in HeLa cells as well as ATG16L1 expression in the intestinal epithelium.28 , 29 Therefore , we can conclude that A20 may inhibit autophagy ."
32027437
sparser
"TRAF6 K63-linked ubiquitination of Beclin 1 was shown to induce autophagy [ xref ]; suggesting a possible feedback loop, the authors also demonstrated that A20 inhibits autophagy by deubiquitinating Beclin 1, thereby inhibiting the autophagy-activating ubiquitination by TRAF6."
24729948
reach
"TNFAIP3 inhibits DLBCL progression by inducing TLR4/MyD88/NF-κB pathway-mediated autophagy."
39190378
eidos
"It has been reported that K48-linked polyubiquitin chains promoted the degradation of proteasome , while K63-linked polyubiquitin chains mediate ubiquitination.22 Thus , these results showed that A20 may suppress autophagy through promoting the degradation of TRAF6 and inhibiting the ubiquitination of TRAF6 ."
32027437
eidos
"In our study , it was proved that A20 inhibited autophagy , reduced TRAF6 expression and decreased the number of TRAP-positive osteoclasts and the areas of hydroxyapatite resorption ."
32027437
eidos
"Thus , A20 deficiency in mice triggers inflammation and autoimmune disorders and might eventually lead to death.13 , 14 , 15 , 16 Many studies have reported that A20 overexpression in human periodontal ligament cells ( hPDLCs ) decreases RANKL-induced osteoclastogenesis in mouse bone marrow-derived macrophages ( BMMs ) and that A20 can inhibit autophagy through limiting the K63-linkage ubiquitination of TRAF6 , or by directly deubiquitinating Beclin1.17 , 18 Numerous studies have shown that periodontal tissues are in a hypoxic microenvironment during periodontitis ."
32027437