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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RTK binds SOS1 and GRB2. 2 / 2

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"The domain organization of SOS1 comprises of a histone fold domain, a Dbl homology (DH)-Pleckstrin homology (PH) domain, a Ras exchanger motif (REM), a CDC25-homology (CDC25-H) domain with GEF activity, and a proline-rich C-terminal region that binds Grb2 and links SOS1 to activated RTKs."

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"Consequently, dn SH3 Grb2 prevents binding of the endogenous Grb2-SOS1 complex to RTKs."

28166272

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...