IndraLab

Statements

CYLD inhibits innate immune response. 8 / 8
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"The higher sensitivity of Cyld -/- mice to DSS induced inflammation indicates a role for CYLD in the negative regulation of the mucosal innate immune response to microorganisms."
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"CYLD inhibits activation of nuclear factor-kappaB (NF-kappaB) and innate immune response."
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"For example, CYLD has been shown to downregulate the inflammatory response following bacterial infection with Escherichia coli by negatively regulating the innate immune response via inhibition of NF-kappaB signalling."
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"Cellular proteins DUBA and CYLD also negatively regulate the innate immune response."
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"Interestingly, CYLD is reported to negatively regulate the innate immune response to infection by Listeria monocytogenes, an intracellular bacterial pathogen recognized by NOD1 and NOD2."
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"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63-based chains [55, 56] , and USP15 inhibits the NFkB pathway by removing K48-Ub from IkBa, preventing its degradation [57] ."
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"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63-based chains [55], [56], and USP15 inhibits the NFκB pathway by removing K48-Ub from IκBα, preventing its degradation [57]."
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"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63 based chains XREF_BIBR, XREF_BIBR, and USP15 inhibits the NFkappaB pathway by removing K48-Ub from IkappaBalpha, preventing its degradation XREF_BIBR."
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