IndraLab

Statements

USP7 increases the amount of KAT5. 3 / 4
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"Since Treg cells isolated from WT or Usp7 fl/fl Foxp3 YFP/Cre mice show comparable expression level of Foxp3 but markedly decreased Tip60 expression, and treatment with USP7-specific inhibitor negligi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP7, a dominant deubiquitinating enzyme in 3T3-L1 adipocytes and mouse adipose tissue, deubiquitinates Tip60 both in intact cells and in vitro and increases Tip60 protein levels."
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"Whereas USP7 indeed increased the Tip60 expression level and concurrently decreased the amount of ubiquitinated Tip60, ATF3 expression promoted the effects of USP7 on Tip60 expression (XREF_FIG, lanes 3 vs. lane 2, and lane 5 vs. lane 4) and ubiquitination (XREF_SUPPLEMENTARY, lane 3 vs. lane 2), suggesting that ATF3 might promote USP7 mediated deubiqutination of Tip60."
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