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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP6 activates CXCL10. 2 / 2

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"This study demonstrates that high USP6 expression is associated with all of these hot TME hallmarks in ES patients , and that USP6 is sufficient to drive an IFN response signature and CXCL10 expression in vitro , as well as intra-tumoral immune cell recruitment and activation in vivo ."

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"As shown in Figure 2C , the first STAT1 site , both NF-kappaB sites , and the ISRE all contributed to activation of the CXCL10 promoter by USP6 + IFNgamma , whereas the AP-1 site was largely dispensable ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...