IndraLab

Statements

USP28 deubiquitinates MYC. 12 / 14
1 1 | 12
reach
"USP28 directly deubiquitinates and stabilizes MYC."
30688660
reach
"USP28 monomers may antagonize ubiquitination of MYC by these enzymes, analogously to the mechanism described for Apc/c-mediated turnover of Claspin (79)."
38227944
reach
"The product of this is lactic acid that changes the pH of the local environment which then promotes the formation of a weakly acidic microenvironment, thus consequently enhancing the deubiquitination of MYC by the deubiquitination enzyme USP28 and improving the stability of MYC [38]."
34875482
reach
"In addition, the ubiquitination of c-Myc is inhibited by the deubiquitinase USP28, which might be carried on FBW7 and operate as a c-Myc protein stabiliser [60]."
36635500
reach
"[6693] USP28 also deubiquitinates Myc salvaging it from proteosomal degradation."
40061651
reach
"An early study showed that USP28 deubiquitinates c-Myc via interacting with Fbw7alpha whereas a recent study reveals that USP37 deubiquitinates c-Myc independently of Fbw7 and c-Myc phosphorylation."
26697836
reach
"Indeed, USP28 de-ubiquitinates and stabilizes MYC, the USP28/MYC interaction being mediated by the F-box protein, FBW7, which targets MYC for degradation by the proteasome."
17961905
reach
"Identified in a retroviral shRNA library screen, USP28 has been shown to decrease MYC polyubiquitination and increase MYC stability by antagonizing the activity of the SCF FBW7 ubiquitin ligase complex [XREF_BIBR]."
27844253
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"Up to now, it has been reported that USP28 suppresses the ubiquitination and degradation of c-Myc through interaction with FBW7α ( Popov et al., 2007 )."
34102342
reach
"A previous study revealed that chronic stress-induced epinephrine promoted the deubiquitylation of MYC by USP28 via lactate dehydrogenase A (LDHA)-dependent metabolic reprogramming in breast cancer."
38689092
reach
"Loss of USP28 promotes MYC ubiquitination (45), predicting a diminished MYC-PAF1 interaction and enhanced expression of MYC target genes in USP28-deficient cells."
38227944