IndraLab

Statements

TXN inhibits MAP3K5. 88 / 94
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"TRX inhibits ASK1 by physical binding ( xref )."
18783313
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"Our data demonstrates the inhibition of the inherited programmed cell death of photoreceptors in the tubby retina by overexpression of Trx; the reduction in the activation of ASK1 and JNK in the photoreceptors of tub and Trx mice compared with Tubby."
20298786
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"Trx can also bind and inhibit apoptosis signal-regulating kinase 1 ( xref ), an upstream kinase in the cellular stress–sensitive pathways (i.e., JNK and p38 pathways)."
19592618
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"Namely, reduced Trx inhibits the function of ASK1, thus preventing apoptosis (Saitoh et al., 1998)."
33134322
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"Conversely, miR-98 and let-7b has been demonstrated to mediate the anti-hypertrophic effect of thioredoxin (Trx1), an ubiquitously expressed antioxidant that inhibits NF-kappaB (nuclear factor kappa-light-chain enhancher of activated B cells), Ras and ASK1 (apoptosis signal regulating kinase 1)."
24113581
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"Furthermore, it functions as an anti-apoptotic factor because Trx inhibits apoptosis signal regulating kinase 1 (ASK1), a critical factor involved in stress induced cell death (Saitoh et al. 1998)."
20619274
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"Trx, which inactivates ASK1 by directly binding to the kinase, itself has catalytic redox activity in a wide variety of intracellular molecular processes."
25068797
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"Alternatively, induction of Trx by cytokines such as IFN-gamma, or oxidative or radiation stresses, blocks ASK1 activation and protects cells against apoptosis."
23106210
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"Trx is known to inhibit the kinase activity of ASK1 by directly interacting with the N-terminal region of ASK1 (Saitoh et al. 1998)."
20619274
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"Moreover, the loss of TXN activity will allow ASK1 to be more readily activated [XREF_BIBR - XREF_BIBR]."
26122708
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"Trx is an inhibitor of apoptosis signal regulating kinase 1 (ASK1) [XREF_BIBR]."
21403879
eidos
"Since the N-terminal Trx-binding domain of ASK1 is necessary and sufficient for its association with Trx , which inhibits ASK1 activity by disrupting N-terminal coiled-coil ( NCC ) domain homophilic interactions [ 32 ] , it is interesting to test whether Trxlp could inhibit the homophilic interaction via the NCC domain of ASK1 ( ASK1-N ) ."
31314784
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"Reduced, but not oxidized TRX1 is able to bind and inhibit ASK1 activity, whereas ASK1 activation by TRX1 oxidation results in apoptosis XREF_BIBR."
28391184
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"We have reasoned that Trx1 inhibits ASK1 induced apoptosis [XREF_BIBR], thus 4HNE induced decrease in Trx1 might promote ASK1 activation."
33493155
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"In the first model (XREF_FIG), Trx1 sequesters ASK1 in an inactive complex and undergoes intramolecular disulfide formation upon TNF-alpha or H 2 O 2 stimulation."
23639002
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"Dephosphorylation of ASK-1 induced TMZ resistance in human glioma cells, and several ASK-1 upstream suppressors, including Trx, PP5, 14-3-3, and Cdc25C, are involved in this phenotypic change induced by dephosphorylation of ASK-1."
36951032
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"Growing evidence shows that increased Trx levels prevent ASK1 activation and subsequently inhibit the activation of the downstream p38 and JNK pathways [XREF_BIBR, XREF_BIBR]."
33643519
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"Trx, which inactivates ASK1 by directly binding to the kinase, itself has catalytic redox activity in a wide variety of intracellular molecular processes."
25068797
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"The study by Saitoh showed that Trx expression inhibits ASK1 activity and that suppressing Trx increases ASK1 activity."
28977868
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"These findings indicate that in female FORKO, ANG II induced cardiac hypertrophy and fibrosis are associated with the TRX downregulation and upregulation of ASK-1 and caspase signaling."
18676690
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"Hence, an alternative regulatory model was presented whereby Trx1 negatively regulates ASK1 signaling under resting conditions by maintaining it in a reduced state (XREF_FIG)."
19957967
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"In its reduced form Trx inhibits apoptosis signal-regulating kinase 1 (ASK1) and the downstream mitogen-activated protein kinase p38 (p38-MAPK)."
25253202
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"Inhibition of Trx by TBP2 activates ASK1, which promotes apoptosis."
19459166
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"In the absence of oxidative stress, Trx inhibits ASK1 kinase activity via direct binding to the N-terminal region of ASK1."
22666632
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"Furthermore, it functions as an anti-apoptotic factor because Trx inhibits apoptosis signal-regulating kinase 1 (ASK1), a critical factor involved in stress-induced cell death ( Saitoh et al. 1998 )."
20619274
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"In basal conditions, thioredoxin (trx) acts to inhibit ASK1 activation and subsequent enzyme activity through a direct interaction XREF_BIBR."
26448396
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"According to this model, TRX inhibits apoptosis signal-regulating kinase 1 and activates nuclear factor-κB, both of which lead to cisplatin resistance [ 20 •• ]."
16765644
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"Our data suggest that ASK1 in cytoplasm and mitochondria mediate distinct apoptotic pathways induced by TNF, and Trx1 and Trx2 cooperatively inhibit ASK1 activities."
15117824
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"Overexpression of Trx1 accelerated the reduction of Ask1, and a redox inactive mutant of Trx1 (C35S) remained trapped with Ask1, blocking its reduction."
17652454
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"ASK1 is normally inhibited by reduced Trx; however, when the Trx is oxidized, it dissociates from ASK1, allowing it to dimerize and self-activate and then activate downstream protein kinase kinases ( xref )."
20050630
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"The results also showed that SF up-regulated Trx, which inhibited ASK1 and downstream p38 activity, thereby decreasing Txnip expression and inhibiting photoreceptor cell apoptosis."
28977868
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"In basal conditions, Ask-1 is inhibited by Trx1 and Trx2 in the cytosol and mitochondria, respectively."
26540198
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"In basal conditions, Ask-1 is inhibited by Trx1 and Trx2 in the cytosol and mitochondria, respectively."
26540198
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"Since Trx1 inhibits apoptosis signal regulating kinase 1 (ASK1)-nduced apoptosis [XREF_BIBR], we test whether 4HNE is involved in the activation of ASK1."
33493155
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"Expression of Trx inhibited ASK1 kinase activity and the subsequent ASK1 dependent apoptosis."
9564042
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"Growing evidence shows that increased Trx levels prevent ASK1 activation and subsequently inhibit the activation of the downstream p38 and JNK pathways [ 50 , 51 ] ."
33643519
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"ASK1 is a major effector of oxidative cell death and is physiologically inhibited by Trx1."
21234411
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"Moreover, TRX inhibited apoptosis signal regulating kinase 1 (ASK1) by promoting the ubiquitination of ASK1, demonstrating the role of TRX beyond ROS removal."
27051644
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"Our current and previous studies also show that Trx1 overexpression in mice inhibits the ASK1 pathway, which could facilitate cancer growth in old animals."
30370017
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"Trx can also scavenge reactive oxygen species (ROS) and directly inhibits proapoptotic proteins such as apoptosis signal regulating kinase 1 (ASK1)."
18979503
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"ASK1 may be redox activated upstream of p38MAPK and JNK to induce cardiomyocyte apoptosis, and ASK1 activity and ASK1 dependent apoptosis are inhibited by Trx1 and Trx2 XREF_BIBR."
21236334
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"The Trx system also has direct antiapoptotic functions, e.g., with reduced Trx1 inhibiting apoptosis signal-regulating kinase 1 and with TrxR1 playing a potential role in normal p53 maturation ."
19766715
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"Through this direct interaction, Trx1 suppresses the kinase activity of ASK-1, thereby inhibiting the apoptotic as well as hypertrophic function of ASK-1 [91,129]."
17007870
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"Additionally, it was shown that TNF-alpha-mediated regulation of ASK-1 is ROS- and redox sensitive and that NAC and TRX, a redox molecule, blockaded the dimerization and the activity of ASK-1 [30,72]."
11841806
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"Trx can directly bind and inhibit ASK-1 or indirectly through inhibition of murine protein serine-threonine kinase 38 (MPK38), a member of the AMP-activated protein kinase-related serine/threonine kinase family that plays an important role in inducing ASK1-, TGF-β-, and p53-mediated apoptosis xref ."
25329456
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"Trx1 suppresses ASK1 activity and promotes ASK1 degradation through directly binding to the N-terminal region of ASK1 ."
34732784
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"Thioredoxin-1 (Trx1), an extensively studied antioxidant, growth regulator, and antiapoptotic protein, is known to interact with and inhibit ASK1 activity [XREF_BIBR], one of the prime mediators of ER stress related apoptotic response."
22474423
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"Trx1 and Trx2 bind directly to the N-terminal regulatory domain of ASK1 and inhibit ASK1 dependent apoptosis."
16987025
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"Apoptosis signal regulating kinase 1 (ASK1), which is a serine/threonine protein kinase of the mitogen activated protein 3kinase (MAP3K) family, is known to interact with Trx; Trx inhibits the kinase [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20307687
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"It has been assumed that Trx1 inhibits the downstream release of ASK1 from the Trx1 and ASK1 complex in the cytosol, resulting in the inhibition of the JNK and p38 apoptotic pathway."
23316132
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"Higher expression of Trx in females potentially prevents ASK1 activation."
19526288
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"In the first mechanism, reduced TRX binds and inhibits ASK1 (apoptosis signal-regulating kinase), while oxidized TRX dissociates from ASK1, which binds TRAF-2 leading to activation of the JNK/p38MAPK pathways and cell death [reviewed by ( xref )]."
20332002
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"Inhibition of Trx by binding to TBP2 activates ASK1 which, in turn, promotes apoptosis by inducing SET1-JNK and MKK3 and MKK6-p 38 signaling cascades, and enhancing the expression of pro apoptotic protein Bim [XREF_BIBR]."
20687783
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"39 In addition to its activity as an oxidoreductase, recent in vitro studies have demonstrated that Trx1 directly interacts with and inhibits the activity of ASK-1, a mitogen activated protein kinase that activates the proapoptotic kinases, MAPK, and JNK."
23846223
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"In addition, Trx1 suppresses apoptosis signal regulating kinase-1 (ASK-1) through direct protein protein interaction and degradation of ASK-1, which inhibits cardiac hypertrophy and apoptosis (reviewed in 20)."
21183740
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"For example, Trx1 inhibits Ras 3 and ASK-1 4, thereby negatively regulating protein kinase cascades known to stimulate hypertrophy."
21183740
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"TRX inhibits ASK1 by physical binding."
18783313
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"50, 51 Increased Trx levels prevent ASK1 activation and subsequently inhibit the activation of the downstream p38 and JNK pathways."
32266795
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"In our previous report, thioredoxin (Trx), which is an antioxidant protein and plays pivotal roles in maintaining intracellular redox balance, inhibited ASK1 kinase activity by direct binding to ASK1 under normal conditions."
20609916
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"In unstressed cells, reduced Trx1 and Trx2 negatively regulate ASK1 by binding to an N-terminal domain, whereas Trx1 and Trx2 oxidation results in their dissociation from ASK1, facilitating ASK1 activation and promoting apoptosis [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
22542445
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"It is worth noting, however, that Trx inhibits both ASK1 and p66 Shc activation under basal conditions and that Prx1 plays auxiliary inhibitory role under oxidative stress."
22448089
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"Trx is an inhibitor of apoptosis signal regulating kinase 1 (ASK1)."
20687783
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"Trx1 is an inhibitor of apoptosis signal regulating kinase 1, a MAPK kinase kinase that can activate MAPK kinase and the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways leading to cell death."
26451472
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"Trx is also an inhibitor of apoptosis signal regulating kinase 1 (ASK1)."
19459166
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"In turn, Trx inhibits the activity of ASK1 and Txnip to inhibit the p38 pathway, thus preventing HG induced photoreceptor cell damage in vitro and in vivo."
28977868
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"Moreover, TRX inhibited apoptosis signal-regulating kinase 1 (ASK1) by promoting the ubiquitination of ASK1, demonstrating the role of TRX beyond ROS removal. xref In most cases, TRX has been shown to possess a protective and anti-apoptotic function."
27051644
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"Inhibition of Trx by binding to TBP2 activates ASK1 which, in turn, promotes apoptosis by inducing SET1-JNK and MKK3 and MKK6-p 38 signaling cascades, and enhancing the expression of pro apoptotic protein, Bim."
20594930
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"Under normal conditions, TRX inhibits the activation of ASK1 via formation of a complex."
34576095
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"According to this model, TRX inhibits apoptosis signal regulating kinase 1 and activates nuclear factor-kappaB, both of which lead to cisplatin resistance [20 **]."
16765644
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"Finally, Trx binds and inactivates apoptosis signal-regulating kinase 1 (ASK1)."
30248944
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"One model posits that Trx1 sequesters ASK1 in an inactive complex and, upon treatment of cells with TNF or H 2 O 2, undergoes intramolecular disulfide formation."
19957967
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"TRX inhibits ASK-1 and p38MAPK to suppress apoptosis [ xref , xref ] and regulates key transcription factors, such as NF-κB, AP-1, and p53 [ xref , xref , xref ]."
| PMC
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"In the cytosol Trx-1 binds to and inhibits ASK-1 activation."
19205032
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"We did not observe obvious changes of the total ASK1 level but results demonstrated that Trx-1 overexpression inhibited hyperoxia induced ASK1 activation."
29599892
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"Trx has been shown to reduce the hyperoxidation of Prx1 and inhibit ASK1 activation by interacting with it under reducing conditions XREF_BIBR, XREF_BIBR."
29707240
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"Trx is a physiological inhibitor of ASK1 located upstream of the p38 and MAPK pathway, and therefore disrupts the p38 and MAPK dependent apoptosis."
33260826
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"Trx inhibited this interaction of ASK1, which was, however, enhanced by expression of TRAF2 or TRAF6 or by treatment of cells with H2O2."
17724081
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"Moreover, inhibition of Trx resulted in activation of endogenous ASK1 activity, suggesting that Trx is a physiological inhibitor of ASK1."
9564042
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"In the reduced form, Trx binds to and inhibits Ask1 activity XREF_BIBR."
23028424
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"Hence, in a reduced environment, thioredoxin (Trx) inhibits Ask1 kinase activity by directly binding to the N-terminal region of Ask1."
30677014
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"In unstressed cells, reduced Trx negatively regulates ASK1 by binding to an N-terminal domain, whereas Trx oxidation results in its dissociation from ASK1 facilitating ASK1 activation and thereby promoting apoptosis [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19703554
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"In the signalosome, Trx inhibits ASK1 activity through direct binding [XREF_BIBR]."
26190663
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"Also, reduced Trx binds and inhibits ASK1, and we noted the dissociation of ASK1 from Trx1 for treatments that oxidized Trx1 ( xref )."
19703554
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"One of the functions of Trx is to prevent cell apoptosis by sequestering the intracellular death signaling ASK1 through its N-terminal end and inhibiting its kinase activity."
23291592
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"Trx is an inhibitor of apoptosis signal regulating kinase 1 (ASK1)."
22127890
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"This inhibition leads to p53 dependent cell cycle arrest or apoptosis [36] or Trx dependent activation of apoptosis signal regulating kinase 1 (ASK1) [37]."
23732520
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"This alternate model suggests Trx1 negatively regulates ASK1 by maintaining its reduced state."
23639002
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"25 The enhancement of the Trx, GSH and Nrf2 systems work together to prevent the activation of ASK1 and subsequent p38- and JNK dependent apoptosis in cerebral I/R injury."
32266795