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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FOXO1 is transcriptionally active. 2 / 2

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bel

"Placing an aspartate residue at Ser-256, to mimic phosphorylation, also induced substantial cytoplasmic localization, even in unstimulated cells. Together, these results provide the first direct evidence that residues within the basic region of the FKHR DNA binding domain are essential for nuclear targetting, and that the introduction of a negative charge at this site is sufficient to disrupt this function."

11237865

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bel

"Western blot analysis revealed that FOXO1a accumulated preferentially in the nucleus upon ROS stimuli, resulting in the transactivation of IRS promoter activity driven by H(2)O(2)-activated FOXO1a."

18035477

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...