IndraLab

Statements

Wnt inhibits SCN5A. 3 / 3
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sparser
"Overexpression or knockdown of Tbx3 directly modified Na v 1.5 and I Na , whereas CRISPR/Cas9-induced mutations at TCF4 binding sites within the Scn5a promoter attenuated Wnt inhibition of Scn5a and Na v 1.5."
32046907
reach
"Moreover, Wnt GOF down-regulates Scn5a and Cx43 in these regions of the ventricles while AVC enriched genes such as Tbx3 and periostin (seen in developing annulus fibrosus) are up-regulated."
25634965
reach
"Overexpression or knockdown of Tbx3 directly modified Na v 1.5 and I Na, whereas CRISPR and Cas9 induced mutations at TCF4 binding sites within the Scn5a promoter attenuated Wnt inhibition of Scn5a and Na v 1.5."
32046907