IndraLab
Statements
✎
reach
"Two independent USP13 shRNAs both decreased PTEN protein expression by 80% and increased phospho-AKT and phospho-FOXO1/3 levels by 3- to 5-fold in SUM159 breast cancer cells, while restoration of PTEN or expression of an RNAi resistant ' silence mutant ' (i.e., no amino acid change) of USP13 (USP13-RE) in USP13 depleted SUM159 cells completely reversed the effect of USP13 shRNA on upregulating the phosphorylation of AKT and FOXO (XREF_FIG and XREF_SUPPLEMENTARY)."
✎
reach
"Reintroduction of USP13 could block the pathway and rescue PTEN protein expression, and thereby inhibited the carcinogenesis of bladder cells."
✎
reach
"Knockdown of USP13 by USP13 shRNA, miR-130b/301b overexpression or NF-kB activation in BC cells leads to the loss of PTEN expression, which was subsequently demonstrated to be reversed by reintroduction of USP13."