IndraLab

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USP13 decreases the amount of PTEN. 7 / 8
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"Furthermore, USP13 overexpression induced phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression and repressed the activation of AKT as well as the expression of the downstream effectors glucose transporter-1 (GLUT1) and hexokinase-2 (HK2)."
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"Reintroduction of USP13 could block the pathway and rescue PTEN protein expression, and thereby inhibited the carcinogenesis of bladder cells."
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"In these tumors, USP13 interacts with and deubiquitinates the tumor suppressor PTEN protein, thereby stabilizing and increasing the expression of PTEN [16–18]."
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"For example, USP13 overexpression induces an increase in the expression of the tumor suppressor PTEN in BC cells through deubiquitylation and stabilization of PTEN, thereby inhibiting tumor growth [ 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of USP13 by USP13 shRNA, miR-130b/301b overexpression or NF-kB activation in BC cells leads to the loss of PTEN expression, which was subsequently demonstrated to be reversed by reintroduction of USP13."
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"Restoring USP13 levels partially inhibits the invasion and migration of tumor cells by stabilizing the expression of PTEN (84)."
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"Two independent USP13 shRNAs both decreased PTEN protein expression by 80% and increased phospho-AKT and phospho-FOXO1/3 levels by 3- to 5-fold in SUM159 breast cancer cells, while restoration of PTEN or expression of an RNAi resistant ' silence mutant ' (i.e., no amino acid change) of USP13 (USP13-RE) in USP13 depleted SUM159 cells completely reversed the effect of USP13 shRNA on upregulating the phosphorylation of AKT and FOXO (XREF_FIG and XREF_SUPPLEMENTARY)."
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