IndraLab

Statements

BAP1 leads to the deubiquitination of Histone on A2. 3 / 3
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"p53 binds to the SLC7A11 promoter, directly suppressing its transcription; the nuclear deubiquitinase (DUB) BAP1 represses SLC7A11 transcription by removing histone 2A ubiquitination from the SLC7A11 promoter; and KEAP1 represses SLC7A11 transcription through degrading NRF2, a master transcription factor of antioxidant response and regulator of SLC7A11."
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"Further mechanistic studies demonstrated that BAP1 suppresses SLC7A11 expression partly by deubiquitinating histone 2A ubiquitination to promote ferroptosis."
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"Recently, it has been found that BAP1 can inhibit the expression of SLC7A11 to suppress the uptake of cystine by deubiquitinating histone 2A on the SLC7A11 promoter."
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