IndraLab

Statements

Phosphorylated TGFBR1 phosphorylates SMAD3. 6 / 6
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"TbetaRI phosphorylation causes phosphorylation of Smad2 and Smad3 proteins, enabling their migration to the nucleus (in association with Smad4) to regulate transcription of TGFbeta target genes."
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"In response to TGF-beta ligands, TbetaRII transphosphorylates TbetaRI, in turn mediates phosphorylation of Smad2 and Smad3."
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"Upon binding of TGF-beta to TbetaRII, TbetaRI is recruited, transphosphorylated and activated to phosphorylate the downstream mediators, SMAD2 and SMAD3."
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"Then the phosphorylated TbetaRI triggers Smad2 and Smad3 phosphorylation."
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"Phosphorylation of TbetaRI activated phosphorylation of Smad2 and Smad3 in cytoplasm XREF_BIBR."
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"The phosphorylated TbetaRI then phosphorylates Smad2 and Smad3, which form a complex with Smad4."
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