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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNQ2 binds IQ. 2 / 2

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"Since inhibition of CaM binding to the IQ motif of KCNQ2 completely blocks the targeting of heteromeric HA-KCNQ3 and KCNQ2 channels from the ER to the axonal surface (XREF_FIG - XREF_FIG), the KCNQ2 subunits with de novo XREF_BIBR - XREF_BIBR and BFNC XREF_BIBR mutations in the IQ motif would likely exert a dominant negative effect by forming channels with KCNQ3 and retaining them in the ER."

25077630

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"These results collectively support the idea that disruption of CaM binding to the IQ motif of KCNQ2 retains intact heteromeric channels in the ER of cultured hippocampal neurons."

25077630

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...