IndraLab

Statements

Acetaldehyde binds USP14. 3 / 3
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"Interestingly, with Ub aldehyde which associates directly with Usp14 and Ubp6, the time to maximal activation was much shorter (< 10 min) than with Ub conjugates."
20005843
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"When Usp14 binds a substrate or Ub aldehyde, the orientation of its C-terminal region undergoes changes in its structure."
20005843
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"Next, we modelled USP14 and, similar to UCHL5, USP14 covalently binds b-AP15 via a 1,4-Michael addition reaction at the thiol group of the Cys114 residue (covalent linkage) with the aldehyde from the small molecule DUB inhibitor (XREF_FIG)."
25691154