IndraLab

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ATM phosphorylates USP10. 29 / 29
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"We further examined the functional significance of USP10 phosphorylation by ATM."
20096447
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"Following DNA damage, ATM phosphorylates USP10, resulting in stabilization of USP10 and allowing it to more efficiently deubiquitinate and recycle cytoplasmic p53 back to the nucleus [XREF_BIBR]."
23151129
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"It is possible that USP10 phosphorylation by ATM hinders USP10 nuclear export and shields it from degradation in the cytoplasm."
20096447
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"Upon DNA damage, USP10 is phosphorylated by ATM, after which it is re-localized to the nucleus where p53 de-ubiquitination occurs, which is the reverse of the function of residual MDM2, which ubiquitinates p53."
32532965
sparser
"Upon induction by DNA damage, a fraction of USP10 is phosphorylated by ATM and translocates to the nucleus where it deubiquitinates p53."
21624367
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"Upon induction by DNA damage, a fraction of USP10 is phosphorylated by ATM and translocates to the nucleus where it deubiquitinates p53."
21624367
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"Importantly, USP10 can be phosphorylated by the ATM kinase, leading to its stabilization and nuclear translocation."
28031783
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"Importantly, USP10 can be phosphorylated by the ATM kinase, leading to its stabilization and nuclear translocation."
25578727
reach
"It is possible that USP10 phosphorylation by ATM hinders USP10 nuclear export and shields it from degradation in the cytoplasm."
20096447
sparser
"Importantly, USP10 can be phosphorylated by the ATM kinase, leading to its stabilization and nuclear translocation."
28031783
sparser
"Following DNA damage, ATM phosphorylates USP10, resulting in stabilization of USP10 and allowing it to more efficiently deubiquitinate and recycle cytoplasmic p53 back to the nucleus [ xref ]."
23151129
sparser
"Importantly, USP10 can be phosphorylated by the ATM kinase, leading to its stabilization and nuclear translocation."
25578727
reach
"USP10 phosphorylation by ATM is required for its stabilization and translocation following DNA damage."
20096447
sparser
"These results suggest that USP10 is phosphorylated by ATM following DNA damage, which contributes to its stabilization."
20096447
sparser
"For example, after DNA damage, Ataxia telangiectasia mutated (ATM)-induced phosphorylation of USP10 at residues Thr42 and Ser337 can promote the stability of USP10 and facilitate its translocation from the cytoplasm to the nucleus."
34177595
sparser
"These results implying that USP10 might be phosphorylated by ATM following DNA damage, which results in USP10 stabilization and relocalization."
20096447
reach
"Following DNA damage, phosphorylation of USP10 by ATM leads to translocation of USP10 into the nucleus, where USP10 deubiquitinates and stabilizes nuclear p53 [XREF_BIBR]."
27844253
sparser
"Mutation of both T42 and S337 (TS/AA) also abolished USP10 phosphorylation by ATM ( xref )."
20096447
sparser
"USP10 phosphorylation by ATM is required for its stabilization and translocation following DNA damage."
20096447
reach
"These results implying that USP10 might be phosphorylated by ATM following DNA damage, which results in USP10 stabilization and relocalization."
20096447
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"Phosphorylation of Usp10 by ATM is also required for Usp10 antioxidant activity in stress granules [XREF_BIBR]."
25962961
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"These results suggest that USP10 is phosphorylated by ATM following DNA damage, which contributes to its stabilization."
20096447
sparser
"Under stress condition, ATM phosphorylates USP10, which then deubiquitinates and targets cytoplasmic p53 back to the nucleus."
29479529
sparser
"DNA damage promotes ataxia telangiectasia mutated (ATM)-dependent phosphorylation of USP10, which undergoes nuclear translocation."
33919439
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"Under stress condition, ATM phosphorylates USP10, which then deubiquitinates and targets cytoplasmic p53 back to the nucleus."
29479529
sparser
"Phosphorylation of Usp10 by ATM is also required for Usp10 antioxidant activity in stress granules [ xref ]."
25962961
sparser
"Moreover, USP10 is mainly localized in the cytosol, where its function is to maintain the levels of p53 and to counteract MDM2-mediated p53 nuclear export under normal conditions. xref Upon DNA damage, USP10 is phosphorylated by ATM, after which it is re-localized to the nucleus where p53 de-ubiquitination occurs, which is the reverse of the function of residual MDM2, which ubiquitinates p53. xref , xref As USP10 plays an anti-cancer role by regulating the nuclear output and degradation of p53 induced by MDM2, down regulating DUBs may have an impact on cancer and other hypoxia related diseases. xref "
32532965
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"On the other hand, a phospho mimetic mutant of USP10-T42E and S337D (TS/ED) translocated to the nucleus in the absence of genotoxic stress (XREF_FIG and XREF_SUPPLEMENTARY), suggesting phosphorylation of USP10 by ATM is sufficient to induce USP10 translocation."
20096447
sparser
"Following DNA damage, phosphorylation of USP10 by ATM leads to translocation of USP10 into the nucleus, where USP10 deubiquitinates and stabilizes nuclear p53 [ xref ]."
27844253