IndraLab

Statements


SIX1 binds USP1 and HSPA9. 3 / 3
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"Functionally, pharmacological or genetic inhibition of the GRP75-USP1-SIX1 protein complex suppresses tumor growth and overcomes the castration resistance of PC cells in vitro and in xenograft mouse models."

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"A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance."

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"Structurally, the C-terminus of GRP75 (433-679 aa) contains a peptide binding domain, which is required for the formation of GRP75-USP1-SIX1 protein complex."