IndraLab

Statements

USP9X deubiquitinates AMOTL2. 2 / 3
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"These results indicate that deubiquitination of AMOTL2 by USP9X depresses LATS1/2 activity and subsequently activates YAP."
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"Importantly, USP9X depletion increased AMOTL2 mono-ubiquitination, an effect that was abolished by co-depletion of WWP1 using two independent small hairpin RNAs (shRNAs), confirming that the two enzymes indeed exhibit contrasting functions on the same AMOTL2 lysine residues (Fig S2B)."
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