IndraLab

Statements

USP9X deubiquitinates AMOTL2. 3 / 3
1 | 2
reach
"These results indicate that deubiquitination of AMOTL2 by USP9X depresses LATS1/2 activity and subsequently activates YAP."
29366444
reach
"Importantly, USP9X depletion increased AMOTL2 mono-ubiquitination, an effect that was abolished by co-depletion of WWP1 using two independent small hairpin RNAs (shRNAs), confirming that the two enzymes indeed exhibit contrasting functions on the same AMOTL2 lysine residues (Fig S2B)."
34404733
ubibrowser
"we report for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition."
26598551