IndraLab
Statements
"we report for the first time that <span class="match term0">USP9X</span> is a deubiquitinase of Angiomotin-like 2 (<span class="match term1">AMOTL2</span>) and that <span class="match term1">AMOTL2</span> mono-ubiquitination is required for YAP inhibition"
reach
"Importantly, USP9X depletion increased AMOTL2 mono-ubiquitination, an effect that was abolished by co-depletion of WWP1 using two independent small hairpin RNAs (shRNAs), confirming that the two enzymes indeed exhibit contrasting functions on the same AMOTL2 lysine residues (Fig S2B)."