IndraLab

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Pyraclofos activates KCNQ2. 6 / 6
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"Expression of individual KCNQ subunits in tsA cells revealed voltage independent augmentation of KCNQ2, but not KCNQ1 nor KCNQ3, currents by NEM indicating that this action on SCG M currents likely localizes to KCNQ2."
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"A number of antibodies to subunits from different classes of potassium channels were used, including the large conductance Ca 2+ -activated K + channel (BK or KCNMA1), the voltage activated K + channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Retigabine, an analogue of flupirtine, shifted the voltage activation of mutated KCNQ2 channels to more hyperpolarized potentials, and also increased the current amplitude [ xref ]."
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"Thus, these PTEN mutations did not fully recapitulate the phenotype of native VSPs.When the mutations were introduced simultaneously into PTEN (A126G and TI167/168ET into P and TI loop, respectively), voltage-dependent stimulation caused a decrease in PLCδ -PH-GFP fluorescence at the membrane (Fig. 4a) and substantially inhibited KCNQ2 currents (Fig. 4b and Fig. S3B)."
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"This substitution led to a shift of voltage dependent activation of KCNQ2 and a dramatic slowing of activation upon depolarization."
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"Retigabine, an analogue of flupirtine, shifted the voltage activation of mutated KCNQ2 channels to more hyperpolarized potentials, and also increased the current amplitude [XREF_BIBR]."
26365409