IndraLab

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USP22 increases the amount of BCL2. 4 / 4
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"Molecular analysis of the tumor tissues showed that USP22 knockdown reduced the levels of cyclin D2, Akt phosphorylation, vimentin, and Bcl-2, whereas upregulated the expressions of E-cadherin, Bax, and cleaved (cl)-caspase-3, which confirmed in vitro findings."
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"This may explain changes in BAD and bcl-2 expression in response to USP22 overexpression.To investigate whether SOS1 plays an essential role in mediating the tumorigenic roles of USP22 in gastric cancer, we silenced its expression in USP22-overexpressing SGC7901 cells."
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"USP22 knockdown also decreased the expression of Bcl-XL and Bcl-2 and increased the expression of cleaved-caspase 3 and cleaved-caspase 9."
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"We also noticed that overexpression of USP22 induced significant alterations in apoptosis-related BAD and bcl-2 expression."
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