IndraLab

Statements

KCND2 activates potassium(1+). 4 / 4
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"We reported recently that the K+ channel Kv4.2 subunit underlies A-type K+ currents in the spinal cord dorsal horn and is modulated by the ERK signaling pathway."
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"Gene deletion of Kv4.2 (Kcnd2) in mice eliminates most of the A-type K+ current in hippocampal and cortical neurons [XREF_BIBR - XREF_BIBR], and increases back propagation of the action potential from the axon to the somatodendritic region [XREF_BIBR]."
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"QT prolongation in Nfx mice was explained by a significant decrease in the fast transient outward potassium (K + ) current (I tof ), caused by the downregulation of K + channel 4.2 subunit (Kv4.2) expression."
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"Kv4.2 mediates the majority of A-type potassium currents in dorsal horn and an increase in A-type currents would be predicted to reduce overall neuronal excitability (Hu et al., 2006)."
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