IndraLab

Statements

ST-539 inhibits USP30. 10 / 10
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reach
"Overall, our results demonstrate the pharmacological inhibition of USP30 by ST-539 modulates PINK1/Parkin dependent mitophagy, and efficiently induces cardiac mitophagy."
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"Our study , both in vitro and in a mouse model , reports that ST-539 inhibits USP30 , effectively activating mitophagy in cells and in the heart ."
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"Effects of USP30 inhibition on mitochondrial function We next investigated if the pharmacological inhibition of USP30 by ST-539 could influence mitochondrial functions ."
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"ST-539 inhibits USP30 and promotes mitophagy."
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"Additionally, the PK/PD and toxicity profiles of ST-539 should allow further preclinical assessment of USP30 inhibition as a therapeutic strategy for a wide variety of diseases."
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eidos
"Overall , our results demonstrate the pharmacological inhibition of USP30 by ST-539 modulates PINK1 / Parkin dependent mitophagy , and efficiently induces cardiac mitophagy ."
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reach
"Together the data imply that the pharmacological inhibition of USP30 by ST-539 marginally alters mitochondrial function, regardless of USP30 expression."
33890401
eidos
"Together the data imply that the pharmacological inhibition of USP30 by ST-539 marginally alters mitochondrial function , regardless of USP30 expression ."
33890401
reach
"Our study, both in vitro and in a mouse model, reports that ST-539 inhibits USP30, effectively activating mitophagy in cells and in the heart."
33890401
reach
"We next investigated if the pharmacological inhibition of USP30 by ST-539 could influence mitochondrial functions."
33890401