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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 inhibits Parkinson Disease. 3 / 3

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"Accordingly, a mutant form of UCH-L1 with decreased E3 ligase activity upon dimerization, but normal DUB activity, decreases PD pathogenesis."

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"In conclusion, this study in a Swedish case-control sample demonstrates that the S18Y variant in UCH-L1 decreases risk of PD and in particular PD with age of onset below 50 years of age and further st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Functional in vivo studies in mice and the even more recent Drosophila model showed that lack of UCHL1 resulted in PD phenotype such as motor dysfunction , instability of ubiquitin level , and exhibit DA neuron degeneration in MPTP-treated conditions [ 55,124 ] ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...