IndraLab

Statements

UCHL1 inhibits Parkinson Disease. 6 / 6
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"Loss of UCHL1 rescues PD phenotypes through stabilizing PKM."
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"Functional in vivo studies in mice and the even more recent Drosophila model showed that lack of UCHL1 resulted in PD phenotype such as motor dysfunction , instability of ubiquitin level , and exhibit DA neuron degeneration in MPTP-treated conditions [ 55,124 ] ."
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"Accordingly, a mutant form of UCH-L1 with decreased E3 ligase activity upon dimerization, but normal DUB activity, decreases PD pathogenesis."
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"Moreover, mutations of parkin, UCHL1 ( Kay et al., 2007 ) and mutations of ATP13A2, which codes for a lysosomal ATPase ( Ramirez et al., 2006 ), have been shown to result in impaired protein degradati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Loss of UCHL1 rescues the PD phenotypes induced by PINK1 and Parkin deficiency."
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"In conclusion, this study in a Swedish case-control sample demonstrates that the S18Y variant in UCH-L1 decreases risk of PD and in particular PD with age of onset below 50 years of age and further st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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