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"In a study on endothelial cells (ECs) Chandrasekharan and colleagues provided an interesting example for a complex metalloproteinase-independent, but EGF-dependent signalling interaction between PAR 1 , the EGFR and the VEGFR, resulting in transcriptional activation by mitogen-activated protein kinase phosphatase 1 (MKP-1), a key signalling mediator in thrombin and VEGF-mediated activation of endothelial cells."