IndraLab

Statements

NOTCH1 increases the amount of USP7. 3 / 3
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"The USP7 gene locus is bound by NOTCH1, which significantly upregulates USP7 levels and activity for USP7 in a subset of T-cell Acute Lymphoblastic Leukemia (T-ALL) cases [XREF_BIBR]."
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"Interestingly, we found that knockdown of NOTCH1 under OBB treatment significantly inhibited USP7 transcription (p<0.01), while silencing FOXO6 with si-FOXO6 (Huh7, p=0.556; Hep3B, p=0.598) and TGF-β- SMAD family member 3 inhibition with TGF-β receptor (Huh7, p=0.552; Hep3B, p=0.908) inhibitor LY2109761 did not clearly affect USP7 transcription under OBB treatment (Figure 3C–E)."
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"Previous reports have documented the transcriptional regulation of USP7, for instance in T-cell acute lymphoblastic leukemia (T-ALL) in which the transcription factor NOTCH1 induces USP7 gene expression, and where USP7 controls the stability of NOTCH1 and the JMJD3 histone demethylase through a positive regulatory loop [XREF_BIBR, XREF_BIBR]."
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