IndraLab

Statements

CTNNB1 bound to TCF_LEF activates CTNNB1. 5 / 5
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"ICAT has been reported to inhibit the interaction between beta-catenin and TCF and impaired the activation of beta-catenin and TCF signaling."
27829235
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"Hence, it has been proposed that while under normoxic conditions beta-catenin binds predominantly to Tcf/Lef and activates classical Wnt and beta-catenin downstream genes, under hypoxic conditions, Hif-1alpha may recruit beta-catenin to alternative binding sites at promoters e.g. promoters that enhance tumor survival [XREF_BIBR]."
23016862
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"Linc00210 blocked the inhibitory role of CTNNBIP1, promoted the interaction between beta-catenin and TCF and LEF complex, and finally activated Wnt and beta-catenin signaling."
29540185
reach
"By interacting with CTNNBIP1, linc00210 blocks the inhibitory role of CTNNBIP1 in Wnt and beta-catenin activation, and enhances the interaction of beta-catenin and TCF and LEF complex, and finally drives Wnt and beta-catenin signaling pathway activation."
29540185
reach
"CTNNBIP1 interacts with beta-catenin, inhibits the interaction between beta-catenin and TCF and LEF complex, and thus blocks the activation of Wnt and beta-catenin signaling."
29540185