IndraLab
Statements
TNFAIP3 inhibits apoptotic process. 33 / 33
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eidos
"One critical finding from this study is that A20 not only completely blocked the transcription of other NF-kappaB target genes known to antagonize JNK signaling , but also effectively suppressed TNF-induced JNK activation and apoptotic cell death in NF-kappaB activation-deficient MEFs ( Figure 2 ) ."
reach
"Consistently, IEC specific deletion of TNFAIP3 (encoding A20), a gene mutated in Crohn 's disease that encodes an E3 ligase editing enzyme involved in dampening NF-kappaB signaling and TNF induced apoptosis, leads to massive IEC apoptosis and increased susceptibility to experimental colitis."
sparser
"The inhibition of TNFα-induced apoptosis by A20 correlates with the inhibition of phospholipase A2, reduced production of reactive oxygen species (ROS), diminished collapse of mitochondrial membrane potential, decreased activation of caspase-3-like proteases and inhibition of JNK (Jäättelä et al., xref ; Wissing et al., xref ; Lademann et al., xref ; Daniel et al., xref ; Won et al., xref )."
eidos
"Apoptosis and pyroptosis of NP cells increased gradually treated with LPS for 12 h , 24 h , and 48 h. Differently , the level of mitophagy increased first and then decreased , and was the highest at LPS treatment for 12 h. Overexpression or knockdown of A20 in NP cells revealed that A20 attenuated the pyroptosis , apoptosis , and production of inflammatory cytokines of NP cells induced by LPS , while A20 sponsored mitophagy , reduced ROS production and collapse of mitochondrial membrane potential ( DeltaPsim ) ."
sparser
"A20 inhibits apoptosis induced by TNF by interfering with the formation of complex I. The concomitant increase in both A20 and cFLIP which would lead to inhibition of complex I and complex II, respectively, may be required for complete protection against apoptosis induced by TNF."