IndraLab

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STAMBP activates TYR. 5 / 5
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"a-melanocyte-stimulating hormone (a-MSH), secreted by the intermediate lobe of the pituitary, induces eumelanin synthesis in murine melanocytes by binding to melanocortin 1-receptor (MC1-R) and activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Tyrosinase activity was enhanced 2- to 3-fold above control by the analogue, but only 1- to 2-fold above control by a-MSH at this 24 h time period."

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"This finding>, c is in accordance with our previous results [17,18] which ' showed that a-MSH and ACTH did not stimulate ty rosinase activity during the logarithmic growth phase of B 16-G4F cells, ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"XREF_BIBR In the recent study by Hur, XREF_BIBR luteolin did not inhibit tyrosinase activation directly, but it concentration-dependently inhibited tyrosinase activation and melanin generation increase by a-MSH in the B16 melanoma cell as well as cAMP generation by MSH and forskolin, which identified the action mechanism of its whitening action generation."

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"A-MSH and NDP-MSH induce skin darkening in man (Lerner and McGuire, 1961; Levine et al., 1991) and have recently been shown to stimulate tyrosinase activity, increase melanogenesis and induce dendrici[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"