IndraLab

Statements

USP14 leads to the ubiquitination of BECN1. 4 / 4
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"USP14 negatively regulates autophagy by cleaving the Lys63-ubiquitin chains and deubiquitylating beclin 1 71."
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"USP14 interacted with tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) and interrupted the association of Beclin 1 with TRAF6, leading to inhibition of TRAF6 mediated ubiquitination of Beclin 1."
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"Based on these previous findings, we hypothesized that the suppression of Beclin 1 ubiquitination by USP14 might be critically associated with TRAF6-mediated ubiquitination in both autophagy and TLR4-mediated signaling."
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"Taken together, our data demonstrate that USP14 can negatively regulate autophagy induction by inhibiting Beclin 1 ubiquitination, interrupting association between TRAF6 and Beclin 1, and affecting TLR4 induced activation of NF-kappaB through deubiquitination of TAB 2 protein."
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