IndraLab

Statements

KCNA5 inhibits cell population proliferation. 12 / 13
| 12
reach
"Promoter Methylation Analysis Reveals that KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation."
26573141
reach
"For instance, the phosphorylation of Kv1.5 inhibited the glial proliferation and retarded scar repair ( Perez-Garcia et al., 2018 ), the enhanced expressions of Kv1.3 could control cell proliferation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34384853
reach
"The EdU assay and CCK-8 assay results consistently indicated that KCNA5 silence significantly promoted GC proliferation ( Fig. 3 G–I)."
32019676
reach
"Polycystic ovary syndrome suppresses KCNA5 expression in granulosa cells, slowing down the proliferation of granulosa (Gao et al. 2020)."
39764877
reach
"In response to chronic hypoxia, hypoxia-inducible fact 1-alpha (HIF1-α) and nuclear factor of activated T-cells (NFAT) are overexpressed causing reduced expression and function of Kv1.5 and thereby stimulating PASMC hypertrophy and cell proliferation [3,88,89,90]."
36291551
reach
"In vitro , miRNA153 increased the level of Kv1.5 in hypoxic PASMCs by targeting NFATc3 and inhibiting their proliferation and apoptosis resistance."
36373478
reach
"Here, we observed that KCNA5 was downregulated in GC from PCOS, and KCNA5 suppressed GC proliferation."
32019676
reach
"We explored the effects of Kv1.5 silencing on proliferation and growth of osteosarcoma cells using CCK-8 and colony formation assays, and we found that Kv1.5 silencing significantly suppressed cell proliferation and growth after a 48-h treatment compared to the control-shRNA or untreated groups in MG-63 cells."
26569226
reach
"Consistent with our findings, KCNA5 was reported to suppress proliferation in HEK293 cells [ 29 ]."
32019676
reach
"Silencing Kv1.5 expression significantly inhibited proliferation and induced cell cycle arrest at the G0/G1 phase in osteosarcoma [29] but supported Ewing sarcoma cell proliferation [30]."
36978819
reach
"The knock-out of Kv1.5 in microglia reduces the production of NO and proliferation post-inflammatory insult (Pannasch et al., 2006) through ERK/MAPK pathway, suggesting the proinflammatory role of this outward potassium channel in multiple microglial functions."
36115552
reach
"Specifically, these studies have demonstrated that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus, and that the consequent suppression of the Kv1.5 ion channel promotes cancer cell proliferation [21]."
39487324