IndraLab

Statements

USP11 is phosphorylated. 8 / 8
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sparser
"Further, FASN activity induced PI3K-mTORC-S6Kinase signaling phosphorylates USP11."
29483509
sparser
"It also important to note that the activity of phosphorylated USP11, under experimental conditions, was more or less equivalent to the wild-type protein revealing phosphorylation plays an important role in stabilizing DUBs substrate interaction( xref )."
31481479
sparser
"Similarly, the Gartenhaus lab using both pharmacological and genetic approaches, reported that FASN induced S6Kinase signaling to phosphorylate USP11 enhancing its interaction and stability of eIF4B in DLBCL consequently promoting oncogenic translation( xref )."
35191952
sparser
"p70-S6Kinase phosphorylated USP11 regulates eIF4B stability."
29483509
rlimsp
"Employing both pharmacological and genetic approaches, we establish that FASN-induced PI3K-S6Kinase signaling phosphorylates USP11 enhancing its interaction with eIF4B and thereby promoting oncogenic translation."
29483509
sparser
"To examine whether USP11 is indeed S6Kinase substrate in tissue culture, we overexpressed USP11 and assessed the phosphorylation of USP11 using phospho-specific antibody that recognizes the optimal pSer substrate."
29483509
sparser
"Employing both pharmacological and genetic approaches, we establish that FASN-induced PI3K-S6Kinase signaling phosphorylates USP11 enhancing its interaction with eIF4B and thereby promoting oncogenic translation."
29483509
sparser
"We found that TGF β -1 has no effect on the expression of USP11, while it increases tyrosine phosphorylation of USP11 in lung fibroblast cells (data not shown)."
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