IndraLab

Statements

WNT11 binds LRP6. 3 / 3
1 | 2
reach
"This could explain the observation that leupeptin caused decreased interaction between Wnt5a or Wnt11 and LRP6."
33391533
reach
"The LRP6 (P1104S) mutation did n't affect the interaction with CTSD, but it could inhibit the interaction of Wnt5a or Wnt11 and LRP6, blocking the degradation of Wnt5a or Wnt11 by CTSD and resulting in pathological cardiac remodeling."
33391533
signor
"Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation."
15578921