IndraLab

Statements

USP22 decreases the amount of TP53. 11 / 11
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"However, at the protein level, USP22 overexpression significantly increased SIRT1 and inhibited p53 and pSTAT3 expression."
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"In addition, USP22 knockdown might downregulate MDM2 and MDMX and upregulate p53 expression, leading to cell cycle arrest [ 64 ]."
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"USP22 overexpression can increase the SIRT1 protein level and decrease the p53 acetylation level, promoting SLC7A11 expression."
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"In fact, USP22 dose-dependently inhibited the levels of acetylation but not protein expression of p53 ( Figures 4 A and 4B )."
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"Furthermore, a positive feedback loop exists between c-MYC and SIRT1, where USP22 increases SIRT1 stability through MYC mediation, concurrently decreasing p53 levels [125]."
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"Downregulation of USP22 by siRNA in the HeLa cell line results in the decreased expression of BMI-1, c-MYC and cyclin D2, but increased expression of p53."
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"The data indicate that the USP22 gene is involved in the regulation of HeLa cell a cell cycle, and USP22 was demonstrated to play an important role in the regulation of human HeLa cell proliferation.I[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 reduces P53 levels by stabilizing SIRT1, thereby inhibiting apoptosis during DNA damage and embryonic development (44)."
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"In HeLa cells, knock-down of USP22 could up-regulate the expression of p53, and overexpression of USP22 could down-regulate the expression of p53."
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"We found that USP22 silencing in A549 and NCI-H460 cells increased the protein expression of p53, p21 and Bax, the key p53 signal molecules (XREF_FIG A), suggesting that p53 activation plays a role in USP22 silencing induced growth inhibition."
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"The loss of USP22 can reduce the transcription of Myc and p53 by removing Ub from H2B.27 USP3 and USP21 also have functions in chromatin modification, leading to aberrant gene transcription.28 Loss of USP3 results in defects of the cell cycle, while USP21 can promote regenerative functions in hepatocytes."
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