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RAF1 phosphorylates MAPK1. 3 / 5
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"Raf-1 is activated by Ras inducing MEK1, ERK1, and ERK2 phosphorylation [XREF_BIBR], while MST2 triggers apoptosis through PUMA and caspases activation."
26057746
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"Here, we show that both HCV genotype 1a and 3 core proteins activate MEK1 and Erk1/2 MAP kinases and that the costitutive expression of the HCV core results in a high basal activity of Raf1 and MAP/kinase/kinase, as determined by endogenous Raf1 in vitro kinase assay and immunodetection of hyperphosphorylated Erk1 and Erk2 even after a serum starvation."
11420671
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"Its phosphorylation by MAP kinase kinase kinase c-Raf leads to activation and phosphorylation of downstream kinases MAPK3/ERK1 and MAPK1/ERK2 whose targets are multiple cytosolic proteins and nuclear [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27132684