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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PTEN decreases the amount of USP13. 1 / 1

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"Expression of USP13 (but not the C345A mutant) in MDA-MB-231 cells, which led to upregulation of PTEN and downregulation of phospho-AKT and phospho-FOXO1/3 (XREF_FIG), significantly inhibited cell proliferation (XREF_FIG), colony formation on soft agar (XREF_FIG), lactate production (XREF_FIG), glucose uptake (XREF_FIG) and tumor growth (XREF_FIG), while knockdown of PTEN (XREF_SUPPLEMENTARY) rescued the proliferation of USP13 overexpressing MDA-MB-231 cells (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...