IndraLab

Statements

STAT2 binds USP18 and IFNAR2. 10 / 10
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"Mapping the STAT2 and USP18 binding to IFNAR2 by cell micropatterning of further deletions and mutations ( xref ) confirmed aa 418-444 of IFNAR2 as a minimal interaction site for STAT2 and USP18."
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"Based on our previous report xref and the results presented above, USP18 interacts with both IFNAR2 and STAT2."
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"Binding of STAT2 and USP18 to IFNAR2 is synergistic, in line with the previous observation that the STAT2-IFNAR2 interaction was strengthened by USP18 xref ."
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"USP18 also interacts with IFNAR2 and STAT2 to block type I interferon signalling in a protease-independent manner."
30126853
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"These results established that USP18 independently interacts with IFNAR2 and STAT2."
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"USP18 binds STAT2 and IFNAR2, displacing JAK1 from the cytoplasmic domain of IFNAR2 and inducing a conformational change in the IFN-IFNAR1-IFNAR2 complex, leading to impaired signal transduction (left)."
34448086
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"The reported interactions between USP18 and IFNAR2 as well as STAT2 remain to be characterised biochemically and structurally."
30126853
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"More detailed analysis of the interaction dynamics of the STAT2–IFNAR2 interaction in the presence of USP18 by FRAP ( xref ) revealed a dissociation rate constant of 0.015 ± 0.005 s −1 ."
25385185
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"We next examined IFNAR2-independent interaction of STAT2 and USP18 in IFNAR2-deficient U5A cells by using cell micropatterning."
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"Taken together, our data suggest that USP18 simultaneously interacts with IFNAR2 via STAT2 in the membrane distal region and directly in the membrane-proximal region ( xref )."
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