IndraLab

Statements

USP4 deubiquitinates PRPF3. 13 / 15
1 1 | 13
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"PRP3 was deubiquitinated by USP4 consistent with a previous report but not by USP15."
28088760
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"In particular, non proteolytic ubiquitylation of the U4/U6 protein Prp3, promoted by the Prp19 complex, is required for stabilization of the U4/U6 * U5 tri-snRNP, while de-ubiquitylation of Prp3 by Usp4 and Sart3 is required for U4 dissociation and recycling."
28379520
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"Moreover, we found that USP15 and USP4 deubiquitinated substrates PRP31 and PRP3 simultaneously."
28088760
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"On the other hand, Usp4 and Sart3 promote de-ubiquitination and recycling of Prp3, and this modification weakens its interaction with Prp8 and allows for the dissociation of U4 during activation of the spliceosome [49]."
| PMC
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"The result shows that USP4 no longer deubiquitinates Prp3 in the presence of SART3 DeltaNLS."
27060135
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"As the splicing cycle progresses, PRPF3 and PRPF31 are deubiquitinated by USP4 and USP15, respectively (Song et al., 2010; Das et al., 2017)."
39286313
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"Prp3 is deubiquitinated by Usp4 and its substrate targeting factor, the U4/U6 recycling protein Sart3, which likely facilitates ejection of U4 proteins from the spliceosome during maturation of its active site."
20595234
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"Moreover, it was reported that Sart3, Usp4 and Usp15 form a complex in order to de-ubiquitinate Prp3 and Prp31 simultaneously."
| PMC
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"U5 tri-snRNP has joined the spliceosome, Usp4 deubiquitinates Prp3, decreasing its affinity for Prp8."
24530854
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"In addition, the other study reports that USP4, the USP15 homolog, binds to Tip110 and deubiquitinates Prp3, component of the U4 snRNP, during the spilceosome cycle ( Song et al., 2010 )."
24984263
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"It is possible that localization of USP15 and USP4 may be regulated by phosphorylation or a nuclear signal such as NLS and NES depending on the cellular conditions.USP15 and USP4 are required for the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31330151
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"Deubiquitination of PRP31 and PRP3 by the USP15, SART3, and USP4 complex decreases the affinity towards PRP8 and this regulation is important for the proper splicing of chromosome segregation related genes such as Bub1 and alpha-tubulin."
28088760
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"Prp3 is deubiquitinated by Usp4, and is therefore unlikely to be a target for Bre5-Ubp3."
29027900