IndraLab

Statements


USP44 deubiquitinates MAD2L1. 2 / 2
1 | 1

reach
"Knocking down USP14 arrests cell cycle at the G2/M phase and inhibits the proliferation and migration of breast cancer cells, USP44 deubiquitinates the APC-inhibitory Mad2 and Cdc20 complex, thereby preventing anaphase onset."

"USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [103] while <span class="match term0">USP44</span> stabilizes <span class="match term1">Mad2</span>/Cdc20 complex inhibiting premature activation of the APC/CCdh1 complex"