IndraLab

Statements

Modified TP53 activates TP53. 7 / 7
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"In most cell types, p53 expression leads to increased PUMA gene expression and subsequent PUMA mediated apoptosis requires functional p53."
17014719
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"RT-PCR revealed that the expression levels of p53, Bax and Beclin 1 were up-regulated in a dose dependent manner, indicating that Beclin 1 was involved in Rapa induced autophagy and Rapa induced apoptosis as well as p53 up-regulation in PC-2 cells."
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"Additionally, forced overexpression of p53 increases both Drp1 expression and its mitochondrial localization in H1299 p53 -/- cells."
28330939
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"Human p53 expression in mouse cells upregulated PIERCE1 expression, suggesting that p53 responsive elements on the PIERCE1 promoter are crucial, but not the p53 protein itself."
32745107
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"Analysis of GFAP expression in transgenic mice with 0,1, or 2 copies of p53 showed that loss of p53 expression also blocked precocious GFAP expression in both N1ICD; hGFAP-cre; p53-/- and N1ICD; hGFAP-cre; p53 +/- mice (XREF_SUPPLEMENTARY)."
23852537
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"Nutlin 3a treatment of wild type p53 expressing cultured cancer cells increases p53 levels and causes p53 mediated transactivation, cell cycle arrest, and apoptosis [XREF_BIBR]."
22703617
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"As expected, dn p53 expression in HFKs caused increased p53 levels, presumably by stabilizing and inactivating endogenous wild type TP53 (Gottlieb et al., 1994)."
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