IndraLab

Statements

STX1A binds KCNB1. 11 / 11
4 1 | 6
sparser
"Indeed, this is true in both rodent and human β-cells, in which we demonstrated that disruption of the Kv2.1–syntaxin 1A interaction impairs depolarization-induced exocytosis and insulin secretion ( xref )."
28607108
biogrid
No evidence text available
22411134
sparser
"Syntaxin 1A alone binds strongly to Kv2.1 and shifts both activation and inactivation to hyperpolarized potentials."
12807875
sparser
"Kv2.1 interacts directly with syntaxin 1A, a plasma membrane t-SNARE component of the vesicle docking and fusion apparatus."
17609479
biogrid
No evidence text available
15518587
biogrid
No evidence text available
15518587
sparser
"Here we demonstrate, using co-immunoprecipitation and immunocytochemistry analyses, the existence of a physical interaction in neuroendocrine cells between Kv2.1 and syntaxin 1A. Furthermore, using concomitant co-immunoprecipitation from plasma membranes and two-electrode voltage clamp analyses in Xenopus oocytes combined with in vitro binding analysis, we characterized the effects of these interactions on the Kv2.1 channel gating pertaining to the assembly/disassembly of the syntaxin 1A/SNAP-25 (target (t)-SNARE) complex."
12807875
biogrid
No evidence text available
22411134
sparser
"This phenomenon relies on Kv2.1 binding to syntaxin 1A via 9 amino acids within the channel intrinsically disordered C terminus."
31308225
sparser
"Colocalization of KCNQ2 and syntaxin 1A at synaptic terminals suggests a role for their interaction in vesicle release, similar to the recently identified novel role for the syntaxin 1A-Kv2.1 interaction in the enhancement of dense-core vesicle release xref , xref ."
19675672
hprd
No evidence text available
12403834