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EDN1 activates EGFR. 35 / 35
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"The EGFR is activated by endothelin-1 in asthmatic airway smooth muscle cells and is involved in airway remodeling in asthma ( xref )."
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"ET-1 addition to ovarian cancer cells increased EGFR transactivation and ovarian cancer cellular proliferation which was inhibited by ZD4054 or gefitinib [XREF_BIBR]."
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"Among downstream events after endothelin receptor activation, ET-1 causes EGF receptor transactivation, which is partly responsible for MAPK activation [XREF_BIBR, XREF_BIBR]."
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"ZD4054 was able to reduce the ET-1-induced EGFR transactivation."
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"Activation of MAPK members was detected following stimulation of cells with transforming growth factor α (TNFα) [12] , as well as through epidermal growth factor receptor activation by EGF (13,14) o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGFR transactivation caused by addition of ET-1 is dependent on generation of ROS, which may reduce essential disulfide bonds impairing phosphotyrosine."
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"Although the ET (A) receptor subtype is not involved in the early activation of MMPs in type 2 diabetes, ET-1 contributes to transactivation of growth promoting and profibrotic EGFR."
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"In HEY and OVCA 433 ovarian carcinoma cells, ET-1 or EGF induced rapid activation of EGFR, p42/44 mitogen activated protein kinase (MAPK), and AKT."
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"The results indicate that the ET A R regulates cytosolic Ca 2+ in NSCLC cells.The ability of ET-1 to cause transactivation of the EGFR was investigated using NSCLC cells."
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"Additionally, ET-1 can stimulate transactivation of EGFR via ET A receptors in rat cardiac fibroblasts [XREF_BIBR]."
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"EGF receptor transactivation by ET-1 is shown for the first time, to be dependent on NOX enzymes."
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"The transactivation of the EGFR and HER2 caused by ET-1 addition to NSCLC cells is blocked by BQ123 (ET A R antagonist), gefitinib (EGFR TKI), PP2 (Src inhibitor), GM6001 MMP inhibitor) and Tiron (superoxide scavenger)."
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"In addition to that, the factors which are well known as inducers of hypertension, such as catecholamine, angiotensinIIand endothelin-1 also activate EGFR through the transactivation of G-protein-coup[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The mechanism is triggered by ET-1, which causes EGFR transactivation."
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"The data presented show that ET-1, TGFbeta, and PGF 2alpha strongly increase both EGF dependent AIG and EGF receptor promoter activity, while BK, LPA, and RA have only a minor effect in both assays."
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"It has been shown that in NRK cells ET-1 complements EGF to induce cell proliferation [16], and that ET-1 upregulates EGF receptor numbers [18]."
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"The ability of ET-1 to cause transactivation of the EGFR was investigated using NSCLC cells."
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"NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI), ROS scavenger N-acetyl cysteine (NAC), and p47phox small interfering RNA knockdown all inhibited the EGFR transactivation induced by ET-1."
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"Altogether these results confirmed that the activation of EGFR by ET-1 is sufficient to induce the accumulation of beta-catenin by concomitant tyrosine phosphorylation and inhibition of its degradativ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In agreement with previous data (Vacca et al., 2000; Rosano et al., 2007a, 2009), we found that, also in SKOV3 cells, exogenous ET-1 induced a rapid EGFR transactivation on tyrosine 845."
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"In oral SCC, ET-1 activates the epidermal growth factor receptor (EGFR) to induce cell motility, which is crucial to metastasis xref ."
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"ET-1 rapidly increased association of EGFR and Shc with glutathione-S-transferase-Grb2 fusion protein."
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"BQ123 in a dose dependent manner inhibited the EGFR and HER2 transactivation caused by ET-1 addition to NSCLC cells."
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"The increase in EGFR transactivation caused by ET-1 addition to ovarian cancer cells is blocked by ZD4054 (ET A R antagonist) or gefitinib [TKI, 36]."
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"In addition to that, the factors which are well known as inducers of hypertension, such as catecholamine, angiotensinⅡand endothelin-1 also activate EGFR through the transactivation of G-protein-coupl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"3.5 ET-1 causes EGFR and HER2 transactivation."
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"This interaction may be crucial to EGF-R transactivation induced by ET-1 since in COS-7 cells; EGF-R transactivation requires the over-expression of Galpha i and betagamma subunits [XREF_BIBR]."
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"Treatment of NSCLC cells with N-acetylcysteine (antioxidant) or Tiron (superoxide scavenger) inhibited the ability of ET-1 to cause EGFR or HER-2 transactivation.ET-1 addition to ovarian cancer cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data showed that ET-1 stimulated c-Src-dependent transactivation of the EGFR and PI3K and Akt cascade, and pretreatment with PP1, AG1478, or LY294002 attenuated phosphorylation of MAPKs, including ERK1/2, p38 MAPK, and JNK1/2, suggesting that ET-1-stimulated activation of MAPKs is mediated through c-Src-dependent transactivation of the EGFR and PI3K and Akt cascade."
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"XREF_FIG shows that 2 min after addition of 1 nM ET-1 to NCI-838 cells, the EGFR tyrosine phosphorylation was moderately increased whereas 10 nM, 100 nM or 1000 nM ET-1 increased strongly EGFR transactivation."
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"The increase in EGFR and HER2 transactivation caused by ET-1 addition to NSCLC cells was inhibited by lapatinib (EGFR and HER2 tyrosine kinase inhibitor (TKI)), gefitinib (EGFR TKI), ZD4054 or BQ-123 (ET A R antagonist), GM6001 (matrix metalloprotease inhibitor), PP2 (Src inhibitor) or Tiron (superoxide scavenger)."
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"Therefore, we hypothesised that ET-1 could induce EGFR dependent beta-catenin nuclear distribution."
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"Addition of ET-1 to NSCLC cells increased EGFR and HER2 transactivation which was inhibited by BQ123 or gefitinib."
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"Fig. 3 A shows that 2 min after addition of 1 nM ET-1 to NCI-838 cells, the EGFR tyrosine phosphorylation was moderately increased whereas 10 nM, 100 nM or 1000 nM ET-1 increased strongly EGFR transac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Addition of ET-1 to NSCLC cells increased EGFR and HER2 transactivation which was inhibited by BQ123 or gefitinib (XREF_FIG)."
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