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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGF leads to the phosphorylation of YAP1. 2 / 2

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"In summary, in EGFR expressing cells EGF activation induces hypo-phosphorylation of YAP and stabilization of TAZ, promote nuclear translocation of YAP/TAZ and their interaction with TEADs, which results in increased transcription of their target genes CTGF, CYR61, and AMOTL2."

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"In vitro, EGF causes a transient increase in YAP1 phosphorylation followed by decreased YAP1 protein with only modest effects on WWTR1 in COCs."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...