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IKK_complex phosphorylates CYLD on S418. 2 / 2

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"Moreover, IKKepsilon, a noncanonical IKK family member, phosphorylates CYLD at serine 418 and reduces its deubiquitinase activity, leading to induction of oncogenic transformation [XREF_BIBR]."

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"Conversely, IKKɛ directly phosphorylates CYLD at Ser418, hereby decreasing its deubiquitinating potential but increasing the IKKɛ-induced cell transformation [41] (Fig. 3) (see Section 6)."

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IKK_complex phosphorylates CYLD on S418. 2 / 2

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