IndraLab

Statements

USP8 activates apoptotic process. 15 / 15
| 1 14
reach
"The FLIP L destabilization and proteasomal degradation are promoted by USP8 knockdown which accelerates to recruit FADD (fas-associated protein with death domain) to form DISC (death-inducing signalin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33600786
reach
"Moreover, down-regulation of USP8 could promote the apoptosis of HER3 positive GC cells and inhibit the proliferation of them by affecting the cell-cycle."
32848421
reach
"Knockdown of USP8 inhibited the proliferation of human lung cancer cells by regulating cell cycle- and apoptosis-related proteins."
33293867
reach
"USP8 expression is higher in ER-positive BC, and upregulation of USP8 mediates cell proliferation and apoptosis and facilitates the cell cycle of BC cells."
36644233
reach
"Knockdown of USP8 inhibited the proliferation of human lung cancer cells by regulating cyclin- and apoptosis-related proteins."
33293867
reach
"Previously, it was reported that knocking down USP8 promotes apoptosis by downregulating FLIP and upregulating cleaved Caspase 3 and cleaved Caspase 8 in HeLa cells (47)."
36338727
reach
"Subsequently, USP8 silencing inhibited cell viability and induced cell apoptosis, these effects were counteracted when FYN expression was upregulated (Figure 4B–D)."
39702934
reach
"These results indicated that down-regulation of USP8 could promote the apoptosis of HER3 positive GC cells and inhibit the proliferation of them by affecting the cell-cycle."
32848421
reach
"USP8 silencing significantly inhibits PCa cell growth, survival, and migration and promotes apoptosis by increasing cleaved Caspase 3 and cleaved Caspase 9."
36338727
eidos
"Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha ."
36644233
reach
"These chalcone derivatives effectively inhibit the activity of DUB, such as USP5, UCH-L3, USP2, UCH-L1, and USP8, leading to irreversible cell cycle arrest in breast, ovarian, and cervical cancer cells (IC50 = 1.5-12.5 µM), as well as inhibiting their proliferation and initiating apoptosis."
39391229
reach
"In the present study, our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8, which were initially showed to induce apoptosis in various cancers."
33319070
reach
"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
36338727
reach
"Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha."
36644233
reach
"The results indicated that the down-regulation of USP8 could significantly promote the apoptosis of NCI-N87 and MKN-45 cells, but it did not work on MGC-803 cells (XREF_FIG)."
32848421