IndraLab

Statements

UCHL5 activates AKT. 4 / 4
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"We verified that UCHL5 activates the AKT/mTOR pathway to enhance migration and proliferation."
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"Overexpression of UCHL5 enhances, while silencing of UCHL5 represses, cancer cell proliferation and migration by c-Myc, SLC25A19, and ICAM5 transformation via AKT/mTOR pathways."
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"According to RNA-Seq analyses and Western blotting experiments, the expression of c-Myc, SLC25A19, and ICAM5 was modified as a result of UCHL5 activating AKT/mTOR signaling in bladder cancer cells."
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"All things considered, our findings show that increased UCHL5 expression stimulates AKT/mTOR signaling, subsequently triggering the expression of c-Myc, SLC25A19, and ICAM5, which in turn promotes carcinogenesis in bladder cancer."
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