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"However, it should be recognized that while we observed that ectopic expression of USP15 induced a significantly higher levels of HBx than USP5, we can not rule out the involvement of other USPs such as USP4 and USP11 which share 71 and 60% similarity at the amino acid level, respectively XREF_BIBR, contributing to HBx deubiquitylation and subsequent increase of HBx levels."